Center for Therapeutic Innovation

Center for Therapeutic Innovation

The University of Miami Center for Therapeutic Innovation has two major foci.

The first is target identification, small molecule discovery and development in a number of different diseases with an emphasis on the emerging field of epigenetics and epigenetic targeting drugs. Other efforts in the group involve more classical drug targets such as GPCRs, kinases and enzymes. Our work encompasses both traditional small molecule development as well as the development of oligonucleotide therapeutics.

The second major focus is on the basic biology underlying disease. This includes efforts to understand Alzheimer’s, cancer, addiction, diabetes, fragile X syndrome, Parkinson’s and several others. Our team of researchers is engaged in seminal work on novel mechanisms in RNA biology and in the understanding the neurobiology of disease. We take an approach where complementary in silico, in vitro and in vivo approaches integrate to uncover disease related biological mechanisms with the vision that our discoveries may lead to novel avenues for therapeutic intervention.

Faculty Members:
Claes Wahlestedt, M.D., Ph.D.
Nagi G. Ayad, Ph.D.
Shaun P. Brothers, Ph.D.
Mohammad Ali Faghihi, M.D., Ph.D.
Jose P. Silva, M.D., Ph.D.