Programs & laboratories : Laboratory of Translational RNA Genomics

Publications

1. Yamanaka Y, Faghihi MA, Magistri M, Alvarez-Garcia O, Lotz M, Wahlestedt C: Antisense RNA Controls LRP1 Sense Transcript Expression through Interaction with a Chromatin-Associated Protein, HMGB2. Cell Rep 2015, 11:967-976.
2. Pronin A, Levay K, Velmeshev D, Faghihi M, Shestopalov VI, Slepak VZ: Expression of olfactory signaling genes in the eye. PLoS One 2014, 9.
3. Halley P, Kadakkuzha BM, Faghihi MA, Magistri M, Zeier Z, Khorkova O, Coito C, Hsiao J, Lawrence M, Wahlestedt C: Regulation of the apolipoprotein gene cluster by a long noncoding RNA. Cell Rep 2014, 6:222-230.
4. Fatemi RP, Velmeshev D, Faghihi MA: De-repressing LncRNA-Targeted Genes to Upregulate Gene Expression: Focus on Small Molecule Therapeutics. Mol Ther Nucleic Acids 2014, 18:45.
5. Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, et al: HuD regulates coding and noncoding RNA to induce APP—>Abeta processing. Cell Rep 2014, 7:1401-1409.
6. Velmeshev D, Magistri M, Faghihi MA: Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders. Mol Autism 2013, 4:2040-2392.
7. Magistri M, Faghihi MA, St Laurent G, 3rd, Wahlestedt C: Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends Genet 2012, 28:389-396.
8. Modarresi F, Faghihi MA, Lopez-Toledano MA, Fatemi RP, Magistri M, Brothers SP, van der Brug MP, Wahlestedt C: Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol 2012, 30:453-459.
9. Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA: Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. Int J Alzheimers Dis 2011, 929042:9.
10. Faghihi MA, Kocerha J, Modarresi F, Engstrom PG, Chalk AM, Brothers SP, Koesema E, St Laurent G, Wahlestedt C: RNAi screen indicates widespread biological function for human natural antisense transcripts. PLoS One 2010, 5:0013177.
11. Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G, 3rd, Wahlestedt C: Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biol 2010, 11:2010-2011.
12. Faghihi MA, Wahlestedt C: Regulatory roles of natural antisense transcripts. Nat Rev Mol Cell Biol 2009, 10:637-643.
13. St Laurent G, 3rd, Faghihi MA, Wahlestedt C: Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer’s disease. Neurosci Lett 2009, 466:81-88.
14. Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, et al: MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci U S A 2009, 106:3507-3512.
15. Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, 3rd, Kenny PJ, Wahlestedt C: Expression of a noncoding RNA is elevated in Alzheimer’s disease and drives rapid feed-forward regulation of beta-secretase. Nat Med 2008, 14:723-730.
16. Shan G, Li Y, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, et al: A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol 2008, 26:933-940.
17. Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C: A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. PLoS One 2008, 3:0001486.
18. Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L, Timmons JA: The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. BMC Genomics 2007, 8:74.
19. Faghihi MA, Wahlestedt C: RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals. Genome Biol 2006, 7:9.
20. Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, et al: Antisense transcription in the mammalian transcriptome. Science 2005, 309:1564-1566.
21. Mottagui-Tabar S, Faghihi MA, Mizuno Y, Engstrom PG, Lenhard B, Wasserman WW, Wahlestedt C: Identification of functional SNPs in the 5-prime flanking sequences of human genes. BMC Genomics 2005, 6:18.
22. Faghihi MA, Mottagui-Tabar S, Wahlestedt C: Genetics of neurological disorders. Expert Rev Mol Diagn 2004, 4:317-332.